منابع مشابه
Divergent RNA transcription
New approaches using biotinylated-psoralen as a probe for investigating DNA structure have revealed new insights into the relationship between DNA supercoiling, transcription and chromatin compaction. We explore a hypothesis that divergent RNA transcription generates negative supercoiling at promoters facilitating initiation complex formation and subsequent promoter clearance.
متن کاملDivergent transcription from active promoters.
Transcription initiation by RNA polymerase II (RNAPII) is thought to occur unidirectionally from most genes. Here, we present evidence of widespread divergent transcription at protein-encoding gene promoters. Transcription start site-associated RNAs (TSSa-RNAs) nonrandomly flank active promoters, with peaks of antisense and sense short RNAs at 250 nucleotides upstream and 50 nucleotides downstr...
متن کاملDivergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells.
Many long noncoding RNA (lncRNA) species have been identified in mammalian cells, but the genomic origin and regulation of these molecules in individual cell types is poorly understood. We have generated catalogs of lncRNA species expressed in human and murine embryonic stem cells and mapped their genomic origin. A surprisingly large fraction of these transcripts (>60%) originate from divergent...
متن کاملConservation of divergent transcription in fungi.
The comparison of fully sequenced genomes enables the study of selective constraints that determine genome organisation. We show that, in fungi, adjacent divergently transcribed (<---->) genes are more conserved in orientation than convergent (--><--) or co-oriented (-->-->) gene pairs. Furthermore, the time divergent orientation of two genes is conserved correlates with the degree of their co-...
متن کاملPerspectives on Unidirectional versus Divergent Transcription.
Sascha H.C. Duttke,1,8 Scott A. Lacadie,4,8 Mahmoud M. Ibrahim,4,5 Christopher K. Glass,2,3 David L. Corcoran,7 Christopher Benner,6 Sven Heinz,2,6 James T. Kadonaga,1,* and Uwe Ohler4,5,* 1Section of Molecular Biology 2Department of Cellular and Molecular Medicine 3Department of Medicine University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA 4Berlin Institute for Medic...
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ژورنال
عنوان ژورنال: Transcription
سال: 2013
ISSN: 2154-1264,2154-1272
DOI: 10.4161/trns.25554